BIOSCIENCE VALUATION

Our Publications

We demonstrate our thought leadership by numerous scientific and business publications.

Business Publications

  • GREUEL, J., BODE-GREUEL, K., LOESER, T. (2020). Creating unique equity stories - Meeting the standards of US capital markets. In CAPITAL MARKET & INVESTMENT 01-2020. P.42-43

 

  • BODE-GREUEL, K. & RIMPLER, M. (2019). Einsatz künstlicher Intelligenz in der Versorgungsforschung und Kommerzialisierung. Pharm. Ind. 81(6). P.766-772

 

  • GREUEL, J. (2017). Portfolio Planning and Risk Management in the Pharmaceutical Industry 1. In THE BIOMEDICAL & LIFE SCIENCES COLLECTION. London: Henry Stewart Talks Ltd. (Online at https://hstalks.com/bs/3471/).

 

  • GREUEL, J. (2017). Portfolio Planning and Risk Management in the Pharmaceutical Industry 2. In THE BIOMEDICAL & LIFE SCIENCES COLLECTION. London: Henry Stewart Talks Ltd. (Online at https://hstalks.com/bs/3472/).

 

  • GREUEL, J. (2016). The Role of Modern Portfolio Management in Pharma Innovation. In SCHUHMACHER, A., HINDER, M. & GASSMANN, O. (eds.). Value Creation in the Pharmaceutical Industry: The Critical Path to Innovation. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA. p.449-458.

 

  • NICKISCH, K. & BODE-GREUEL, K. (2016). Biosimilars Or Biobetters: Make Your Decisions Wisely. Research & analysis Journals. 2 (8). p.530-535.

 

  • BODE-GREUEL, K. & NICKISCH, K. (2014). Deciding between biobetter versus biosimilar development options based on net present value calculations. Journal of Commercial Biotechnology. 20 (2). p.21-31.

 

  • NICKISCH, K. & BODE-GREUEL, K. (2013). NPV modelling for the selection of value-creating biosimilar development candidates. Journal of Commercial Biotechnology. 19 (1). p.24-32.

 

  • SCHRÖDER-BERNHARDI, D., ENGELHARD, J., WANG, Y., BUSCH, S., BODE-GREUEL, K. (2016). Ein nationales Typ-2-Diabetes-Register. Pharm. Ind. 78(3). P.324-330

 

  • BODE-GREUEL, K. (2011). Management strategischer und operativer Risiken in der Arzneimittelentwicklung. Pharmazeutische Medizin. 13 (3). p.178-183.

 

  • BODE-GREUEL, K. & WAGNER, C. (2011). Consultants' Perspectives: Bioscience Valuation. Focus Oncology. 3. p.13-17.

 

  • BODE-GREUEL, K. (2010). Optimierung der Risikostruktur klinischer Engtwicklungsprojekte. DGPharMed News. 12 (3). p.111-115.

 

  • BODE-GREUEL, K. & GREUEL, J. (2010). Bewertung von Biotech-Unternehmen. In DRUKARCZYK, J. & ERNST, D. (eds.). Branchenorientierte Unternehmensbewertung. 3rd Ed., Munich: Verlag Franz Vahlen. p.293-308.

 

  • BODE-GREUEL, K., GREUEL, J. and NICKISCH, K. (2009). How can pharmaceutical and biotech companies maintain a high profitability? Journal of Commercial Biotechnology. 15 (4). p.309-323.

 

  • BODE-GREUEL, K. & NICKISCH, K. (2008). Value-driven project and portfolio management in the pharmaceutical industry: Drug discovery versus drug development - Commonalities and differences in portfolio management practice. Journal of Commercial Biotechnology. 14 (4). p.307-325.

 

  • GREUEL, J. (2008). Pharma and Biotech: Is it possible to continue growing? Pharma Focus Asia. 6. p.6-9.

 

  • GREUEL, J. (2005). Assessing the economics of biogenerics. Journal of Generic Medicines. 2 (2). p.153-160.

 

  • BODE-GREUEL, K. & GREUEL, J. (2005). Determining the value of drug development candidates and technology platforms. Journal of Commercial Biotechnology. 11 (2). p.155-170.

 

  • GREUEL, J. (2002). The R&D value conundrum. Current Drug Discovery. July. p.37-42.

 

  • LOCH, C. & BODE-GREUEL, K. (2001). Evaluating growth options as sources of value for pharmaceutical research projects. R&D Management . 31 (2). p.231-248.

 

  • BODE-GREUEL, K. (2000). Real Options Evaluation in Pharmaceutical R&D: A New Approach to Financial Project Evaluation. SCRIP Reports. BS1038, 17th February. London: PJB Publications Ltd.

 

  • BODE-GREUEL, K. (1998). Making wise decisions in pharmaceutical investment. Scrip Magazine. June. p.27-28.

 

  • BODE-GREUEL, K. (1997). Financial Project Evaluation and Risk Analysis in Pharmaceutial Development. SCRIP Reports. BS890, 27th November. London: PJB Publications Ltd.

Scientific Publications

  • HACHATURYAN, V., ADAM, M., FAVARETTI, C., GREUEL, M., GATES, J., BÄRNIGHAUSEN, T., & VANDORMAEL, A. (2021). Reactance to Social Authority in a Sugar Reduction Informational Video: Web-Based Randomized Controlled Trial of 4013 Participants. Journal of medical Internet research, 23(11), e29664. https://doi.org/10.2196/29664

 

  • AWWAD, I., GREUEL, S., TACKE, F., & FISCHER, C. (2021). Haemorrhagic ulcerative duodenitis in a patient with COVID-19 infection: clinical improvement following treatment with budesonide. BMJ open gastroenterology, 8(1), e000757. https://doi.org/10.1136/bmjgast-2021-000757

 

  • KRUSE, J. M., ZICKLER, D., LÜDEMANN, W. M., PIPER, S. K., GOTTHARDT, I., IHLOW, J., GREUEL, S., HORST, D., KAHL, A., ECKARDT, K. U., & ELEZKURTAJ, S. (2021). Evidence for a thromboembolic pathogenesis of lung cavitations in severely ill COVID-19 patients. Scientific reports, 11(1), 16039. https://doi.org/10.1038/s41598-021-95694-0

 

  • ASCHMAN, T., SCHNEIDER, J., GREUEL, S., MEINHARDT, J., STREIT, S., GOEBEL, H. H., BÜTTNEROVA, I., ELEZKURTAJ, S., SCHEIBE, F., RADKE, J., MEISEL, C., DROSTEN, C., RADBRUCH, H., HEPPNER, F. L., CORMAN, V. M., & STENZEL, W. (2021). Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died. JAMA neurology, 78(8), 948–960. https://doi.org/10.1001/jamaneurol.2021.2004

 

  • VANDORMAEL, A., ADAM, M., GREUEL, M., GATES, J., FAVARETTI, C., HACHATURYAN, V., & BÄRNIGHAUSEN, T. (2021). The Effect of a Wordless, Animated, Social Media Video Intervention on COVID-19 Prevention: Online Randomized Controlled Trial. JMIR public health and surveillance, 7(7), e29060. https://doi.org/10.2196/29060

 

  • GREUEL, S., IHLOW, J., DRAGOMIR, M. P., STREIT, S., CORMAN, V. M., HABERBOSCH, L., WINKLER, D., MEINHARDT, J., ASCHMAN, T., SCHNEIDER, J., TROTSYUK, I., KUNZE, C. A., MAURER, L., RADBRUCH, H., HEPPNER, F. L., HORST, D., & ELEZKURTAJ, S. (2021). COVID-19: Autopsy findings in six patients between 26 and 46 years of age. International journal of infectious diseases: IJID : official publication of the International Society for Infectious Diseases, 108, 274–281. https://doi.org/10.1016/j.ijid.2021.05.069

 

  • VANDORMAEL, A., ADAM, M., HACHATURYAN, V., GREUEL, M., FAVARETTI, C., GATES, J., & BAERNIGHAUSEN, T. (2021). Reactance to Social Authority in Entertainment-Education Media: Protocol for a Web-Based Randomized Controlled Trial. JMIR research protocols, 10(5), e25343. https://doi.org/10.2196/25343

 

  • ELEZKURTAJ, S., GREUEL, S., IHLOW, J., MICHAELIS, E. G., BISCHOFF, P., KUNZE, C. A., SINN, B. V., GERHOLD, M., HAUPTMANN, K., INGOLD-HEPPNER, B., MILLER, F., HERBST, H., CORMAN, V. M., MARTIN, H., RADBRUCH, H., HEPPNER, F. L., & HORST, D. (2021).  Causes of death and comorbidities in hospitalized patients with COVID-19. Scientific reports, 11(1), 4263. https://doi.org/10.1038/s41598-021-82862-5

 

  • IHLOW, J., MICHAELIS, E., GREUEL, S., HEYNOL, V., LEHMANN, A., RADBRUCH, H., MEINHARDT, J., MILLER, F., HERBST, H., CORMAN, V. M., WESTERMANN, J., BULLINGER, L., HORST, D., VON BRÜNNECK, A. C., & ELEZKURTAJ, S. (2021). B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 103, 628–635. https://doi.org/10.1016/j.ijid.2020.12.078

 

  • VANDORMAEL, A., ADAM, M., GREUEL, M., & BÄRNIGHAUSEN, T. (2020). An entertainment-education approach to prevent COVID-19 spread: study protocol for a multi-site randomized controlled trial. Trials, 21(1), 1025. https://doi.org/10.1186/s13063-020-04942-7

 

  • MEINHARDT, J., RADKE, J., DITTMAYER, C., FRANZ, J., THOMAS, C., MOTHES, R., LAUE, M., SCHNEIDER, J., BRÜNINK, S., GREUEL, S., LEHMANN, M., HASSAN, O., ASCHMAN, T., SCHUMANN, E., CHUA, R. L., CONRAD, C., EILS, R., STENZEL, W., WINDGASSEN, M., RÖSSLER, L., … HEPPNER, F. L. (2021). Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nature neuroscience, 24(2), 168–175. https://doi.org/10.1038/s41593-020-00758-5

 

  • GRUBER, A. D., OSTERRIEDER, N., BERTZBACH, L. D., VLADIMIROVA, D., GREUEL, S., IHLOW, J., HORST, D., TRIMPERT, J., & DIETERT, K. (2020). Standardization of Reporting Criteria for Lung Pathology in SARS-CoV-2-infected Hamsters: What Matters?. American journal of respiratory cell and molecular biology, 63(6), 856–859. https://doi.org/10.1165/rcmb.2020-0280LE

 

  • VANDORMAEL, A., ADAM, M., GREUEL, M., & BÄRNIGHAUSEN, T. (2020). A short, animated video to improve good COVID-19 hygiene practices: a structured summary of a study protocol for a randomized controlled trial. Trials, 21(1), 469. https://doi.org/10.1186/s13063-020-04449-1

 

  • ISLER, J., SAWADOGO, N. H., HARLING, G., BÄRNIGHAUSEN, T., ADAM, M., KAGONÉ, M., SIÉ, A., GREUEL, M., & MCMAHON, S. A. (2019). Iterative Adaptation of a Mobile Nutrition Video-Based Intervention Across Countries Using Human-Centered Design: Qualitative Study. JMIR mHealth and uHealth, 7(11), e13604. https://doi.org/10.2196/13604

 

  • GREUEL, S., FREYER, N., HANCI, G., BÖHME, M., MIKI, T., WERNER, J., SCHUBERT, F., SITTINGER, M., ZEILINGER, K., & MANDENIUS, C. F. (2019). Online measurement of oxygen enables continuous noninvasive evaluation of human-induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow-fiber bioreactor. Journal of tissue engineering and regenerative medicine, 13(7), 1203–1216. https://doi.org/10.1002/term.2871

 

  • GREUEL, S., HANCI, G., BÖHME, M., MIKI, T., SCHUBERT, F., SITTINGER, M., MANDENIUS, C. F., ZEILINGER, K., & FREYER, N. (2019).  Effect of inoculum density on human-induced pluripotent stem cell expansion in 3D bioreactors. Cell proliferation, 52(4), e12604. https://doi.org/10.1111/cpr.12604

 

  • FREYER, N., KNÖSPEL, F., DAMM, G., GREUEL, S., SCHNEIDER, C., SEEHOFER, D., STÖHR, T., PETERSEN, K. U., & ZEILINGER, K. (2019). Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system. Drug design, development and therapy, 13, 1033–1047. https://doi.org/10.2147/DDDT.S186759

 

  • FREYER, N., GREUEL, S., KNÖSPEL, F., GERSTMANN, F., STORCH, L., DAMM, G., SEEHOFER, D., FOSTER HARRIS, J., IYER, R., SCHUBERT, F., & ZEILINGER, K. (2018). Microscale 3D Liver Bioreactor for In Vitro Hepatotoxicity Testing under Perfusion Conditions. Bioengineering (Basel, Switzerland), 5(1), 24. https://doi.org/10.3390/bioengineering5010024

 

  • MEIER, F., FREYER, N., BRZESZCZYNSKA, J., KNÖSPEL, F., ARMSTRONG, L., LAKO, M., GREUEL, S., DAMM, G., LUDWIG-SCHWELLINGER, E., DESCHL, U., ROSS, J. A., BEILMANN, M., & ZEILINGER, K. (2017).  Hepatic differentiation of human iPSCs in different 3D models: A comparative study. International journal of molecular medicine, 40(6), 1759–1771. https://doi.org/10.3892/ijmm.2017.3190

 

  • FREYER, N., GREUEL, S., KNÖSPEL, F., STRAHL, N., AMINI, L., JACOBS, F., MONSHOUWER, M., & ZEILINGER, K. (2017). Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture. International journal of molecular sciences, 18(8), 1724. https://doi.org/10.3390/ijms18081724

 

  • KLISCH, J., BODE-GREUEL, K., HORVÁTH, E., KLISCH, C. and ELS, T. (2003). Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil. Neurosci Lett. 15th May. 342 (1-2). p.25-28.

 

  • DE VRY, J., SCHOHE-LOOP, R., HEINE, H., GREUEL, J., MAULER, F., SCHMIDT, B. and GLASER, T. (1998). Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. Journal of Pharmacology and Experimental Therapeutics. 284 (3). p.1082-94.

 

  • SOMMERMEYER, H., SCHREIBER, R., GREUEL, J., DE VRY, J. and GLASER, T. (1993). Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates. Eur J. Pharmacol. 10th August. 240 (1). p.29-37.

 

  • SIRETEANU, R., SINGER, W., FRONIUS, M., GREUEL, J., BEST, J., FIORENTINI, A., BISTI, S., SCHIAVI, C. and CAMPOS, E. (1993). Eye alignment and cortical binocularity in strabismic kittens: a comparison between tenotomy and recession. Vis Neurosci. May-June. 0 (3). p.541-9.

 

  • KLISCH, J. & BODE-GREUEL, K. (1992). Ketanserin reduces neuronal calcium accumulation and cell death in the hippocampus of the Mongolian gerbil after transient forebrain ischemia. Brain Res. 24th April. 578 (1-2). p.1-7.

 

  • GREUEL, J., GLASER, T. (1992). The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur J Pharmacol. 11th February. 211(2). p.211-9.

 

  • BODE-GREUEL, K. & SINGER, W. (1991). Development changes of calcium currents in the visual cortex of the cat. Exp Brain Res. 84 (2). p.311-8.

 

  • BODE-GREUEL, K., KLISCH, J., HORVÁTH, E., GLASER, T. and TRABER, J. (1990). Effects of 5-hydroxytryptamine1A-receptor agonists on hippocampal damage after transient forebrain ischemia in the Mongolian gerbil. Stroke. 21st December (12 Suppl). IV. p.164-6.

 

  • LUHMANN, H., GREUEL, J., SINGER, W. (1990). Horizontal Interactions in Cat Striate Cortex: II. A Current Source-Density Analysis. Eur J. Neurosci. 2 (4). p.358-368.

 

  • LUHMANN, H., GREUEL, J. and SINGER, W. (1990). Horizontal Interactions in Cat Striate Cortex: III. Ectopic Receptive Fields and Transient Exuberance of Tangential Interactions. Eur J. Neurosci. 2 (4). p.369-377.

 

  • BODE-GREUEL, K., SINGER, W. (1989). The development of N-methyl-D-aspartate receptors in cat visual cortex. Brain Res Dev Brain Res. 1st April. 46 (2). p.197-204.

 

  • GREUEL, J., LUHMANN, H. and SINGER, W. (1988). Pharmacological induction of use-dependent receptive field modifications in the visual cortex. Science. 7th October. 242 (4875). p.74-7.

 

  • BODE-GREUEL, K., SINGER, W. (1988). Developmental changes of the distribution of binding sites for organic Ca2+-channel blockers in cat visual cortex. Exp Brain Res. 70 (2). p.266-75.

 

  • GREUEL, J., LUHMANN, H. and SINGER, W. (1987). Evidence for a threshold in experience-dependent long-term changes of kitten visual cortex. Brain Res. July. 431 (1). p.141-9.

 

  • ALTMANN, L., LUHMANN,H., GREUEL, J., SINGER, W. (1987). Functional and neuronal binocularity in kittens raised with rapidly alternating monocular occlusion. J. Neurophysiol. November. 58 (5). p.965-80.

 

  • BODE-GREUEL, K., SINGER, W. and ALDENHOFF, J. (1987). A current source density analysis of field potentials evoked in slices of visual cortex. Exp Brain Res. 69 (1). p.213-9.